Parkinson's disease: symptoms, diagnosis and treatment

This text outlines much important information related to this complex disease, from its symptoms and diagnosis to treatment options and tips for managing everyday life. It aims to provide a deeper understanding of Parkinson's disease and to be of use to both patients and their families.

What is Parkinson's disease?

Parkinson's disease is a neurological disorder that most often affects people over the age of 50, but it can also affect younger individuals. Parkinson's is characterized by a lack of dopamine in the brain, which leads to problems with motor skills and movement.

A brief history of Parkinson's disease

Parkinson's disease was named after the British physician James Parkinson, who first described the disease in 1817. Since then, there have been huge advances in research, but there is still much to be discovered.

Parkinson's disease is one of the oldest described diseases in medical history. Although it was first described by James Parkinson over 200 years ago, much is still unknown about its exact causes and mechanisms. Researchers around the world are constantly working to find new ways to treat and understand the disease.

In recent years, research into Parkinson's disease has made significant progress. By studying brain function and investigating genetic factors, researchers have been able to gain a deeper understanding of the complex nature of the disease. This has opened the door to new treatments and therapies that can improve the quality of life for people living with Parkinson's disease.

How does Parkinson's disease affect the nervous system?

Parkinson's disease mainly affects the central nervous system and causes problems with movement. This is because the disease leads to the loss of dopamine-producing cells in the brain. Dopamine is a neurotransmitter that is important for transmitting messages between nerve cells. When there is a lack of dopamine, the brain has difficulty controlling and coordinating movements, leading to the characteristic symptoms of patients with Parkinson's disease.

In addition to motor problems, Parkinson's disease can also affect other parts of the nervous system. Some patients may experience cognitive difficulties, such as memory loss and difficulty concentrating. Others may experience emotional changes, such as depression or anxiety. It is important to understand that Parkinson's disease is a complex disease that can affect each individual in different ways.

To better understand how Parkinson's disease affects the nervous system, research continues to investigate the underlying mechanisms of the disease. By studying the structure and function of the brain, researchers hope to find new ways to treat and prevent Parkinson's disease in the future.

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Symptoms of Parkinson's disease

Parkinson's disease is a neurological disorder that affects movement and motor functions. The symptoms of Parkinson's disease can vary from person to person and develop gradually over time.

Early signs of the disease

It can be difficult to detect Parkinson's disease in its early stages, as the symptoms can be subtle. Common early signs include shaking or trembling of the extremities, stiffness in the arms and legs, and difficulty performing fine motor movements. It is important to pay attention to these early signs in order to get early diagnosis and treatment.

In addition to motor symptoms, Parkinson's disease can also affect non-motor functions. Many patients also experience cognitive problems, such as memory loss and difficulty concentrating. Depression and anxiety are also common in people with Parkinson's disease. In cognitive disease due to Parkinson's, the parkinsonian symptoms come first and cognitive impairment comes later.

Progression of symptoms

As the disease progresses, symptoms may become more obvious and affect daily life more significantly. Patients may experience difficulty walking and balance problems, increasing the risk of falls. Other common symptoms include impaired speech, changes in facial expression and disturbances in sleep. It is important to understand that Parkinson's disease affects each individual differently, and that symptoms can vary in intensity and speed.

There is no cure for Parkinson's disease, but there are various treatment options that can help relieve symptoms and improve quality of life for patients. Drugs that increase dopamine production in the brain are often used to reduce motor symptoms. Physiotherapy and occupational therapy can also be helpful in improving movement and everyday functions.

It is important that people with Parkinson's disease receive support and understanding from family members and caregivers. Living with Parkinson's disease can be challenging, but with the right treatment and support, patients can continue to live a meaningful and active life.

Diagnosing Parkinson's disease

Getting an accurate diagnosis is an important part of managing Parkinson's disease. Common symptoms include tremor (shaking), stiffness, slowness of movement and balance problems. To make a diagnosis, doctors need to carefully evaluate the patient's medical history and conduct various tests.

Medical tests for Parkinson's

Diagnosing Parkinson's disease can sometimes be challenging, as there is no specific test that can confirm the disease. Instead, doctors use a combination of the patient's medical history, physical examinations and neurological tests to make a diagnosis.

An important part of the diagnosis is to rule out other possible causes of the symptoms. More advanced tests such as magnetic resonance imaging (MRI) or positron emission tomography (PET) may also be necessary to get a clearer picture of the brain and rule out other neurological diseases.

In addition to these tests, doctors may also use blood tests to examine the levels of various substances in the body. This can provide additional information about the patient's condition and help confirm the diagnosis.

Differences between Parkinson's and other neurological diseases

It is important to distinguish Parkinson's disease from other similar neurological disorders, as the symptoms can be similar. For example, another common condition that can be confused with Parkinson's is essential tremor. To make an accurate diagnosis, doctors may use specific criteria and testing to rule out other conditions and establish Parkinson's disease.

An important difference between Parkinson's disease and essential tremor is that tremor in Parkinson's is usually more pronounced at rest and improves with movement, while essential tremor tends to be more pronounced with movement.

Other neurological diseases that can be similar to Parkinson's include Lewy body dementia and progressive supranuclear palsy. These diseases also have similar symptoms, but differ in the specific changes in the brain that they cause.

You can read more about Lewy body dementia here.

By carefully evaluating the patient's symptoms, medical history and conducting various tests, doctors can make an accurate diagnosis and distinguish Parkinson's disease from other neurological disorders.

We help those who experience memory problems

With extensive experience in helping individuals with concerns about cognitive disorders, we offer digital assessment. You can see a specialist right away - from the comfort of your own home.

Treatment options for Parkinson's disease

When it comes to treating Parkinson's disease, there are various options to consider. In this section, we look at the most common treatment methods to relieve symptoms and improve the quality of life for patients with Parkinson's.

Medical treatment and its effects

Medication is often the first step in managing Parkinson's disease. Commonly prescribed drugs include levodopa, dopamine agonists and monoamine oxidase (MAO-B) inhibitors. These drugs work by either increasing the levels of dopamine in the brain or by improving the brain's ability to use dopamine more efficiently. It is important to remember that the effect of drug treatment can vary between individuals and that adjustments to the dosage and type of medication may be required over time.

In addition to the usual drugs, there are also other medical treatment options that can be considered to manage Parkinson's disease. One such treatment is apomorphine, a dopamine agonist administered through a subcutaneous injection. Apomorphine can be used as an emergency treatment to quickly relieve motor symptoms during 'off periods' when drug treatment is not effective enough.

Another medical treatment method that may be useful for some patients is the use of MAO-B inhibitors in combination with levodopa. These drugs can help delay the breakdown of dopamine in the brain and thus prolong the effect of levodopa treatment.

Surgical procedures for Parkinson's disease

In some cases, surgery may be an option for managing Parkinson's disease. Deep brain stimulation (DBS) is a common surgical treatment to relieve severe motor symptoms. During a DBS operation, electrodes are implanted in specific parts of the brain responsible for movement control. Electronic impulses are then sent from an external stimulator to the brain to regulate and relieve symptoms. It is important to note that surgery is a last resort and is only recommended for some patients who do not respond well enough to medical treatment.

Another surgical treatment method that can be considered is pallidotomy. Pallidotomy involves removing or destroying a small part of the brain, specifically the globus pallidus, to reduce unwanted motor symptoms. This type of surgery can be effective in reducing tremor and rigidity in some patients.

It is important to remember that surgical procedures for Parkinson's disease are complex and not suitable for all patients. A careful evaluation of the patient's condition and symptoms is done before considering surgery as a treatment option.

Living with Parkinson's disease

It's important to remember that Parkinson's is a chronic disease, but that doesn't mean you have to let it stop you from living a meaningful and enjoyable life.

Parkinson's disease is a neurological disorder that affects movement and muscle control. It is common for people with Parkinson's to experience symptoms such as tremor (shaking), stiffness, and difficulty moving. But it is also important to understand that Parkinson's disease can affect people in different ways, and symptoms can vary from person to person.

An important part of living well with Parkinson's disease is managing daily activities in a way that works for you. Maintaining an active and healthy lifestyle can have a positive effect on the disease. Regular exercise and physical activity can help improve muscle strength, balance and mobility. Physiotherapy and occupational therapy can also be useful to help patients manage everyday activities, such as dressing or eating.

In addition to managing the physical aspects of the disease, it is also important to have support and community when living with Parkinson's disease. There are various support groups and organizations that offer advice, information and resources for both patients and families. These groups can be a valuable source of support, understanding and community for anyone affected by Parkinson's disease.

Living with Parkinson's disease can be challenging, but it is important to remember that there is help and support available that is both possible and important. By getting involved in support groups and taking advantage of the resources available, you can get the support and knowledge needed to manage the disease in the best possible way.

In conclusion, we hope that this article has given you a comprehensive overview and understanding of Parkinson's disease. It is important to remember that each individual's experience of the disease is unique, and we encourage you to seek additional information and support from medical experts and support groups. With knowledge and the right support, you can continue to live your best life despite the challenges of Parkinson's disease.

Johan Sundelöf, Consultant, Specialist in Geriatrics and Palliative Medicine
Reviewed by: Johan Sundelöf, Consultant, Specialist in Geriatrics and Palliative Medicine
Updated: December 4, 2023
Published: December 15, 2020

What is dementia?How common is dementia?Diseases of the brainAlzheimer's diseaseVascular dementiaLewy body dementiaForehead dementia / Frontotemporal dementia diseaseParkinson's diseaseAlcohol-induced dementia and Wernicke-Korsakoff syndromeNormal pressure hydrocephalus (iNPH)Rare dementia diseasesHeredity

Brain diseases

Alzheimer's disease

Vascular dementia

Lewy body dementia

Frontotemporal dementia

Parkinson's disease

Alcohol-induced dementia and Wernicke-Korsakoff syndrome

Normal pressure hydrocephalus (iNPH)

Rare dementias

Heredity

Treatment

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